FORMULATION AND IN VITRO EVALUATION OF ORAL DISINETGRATING FILM OF ROPINIROLE HYDROCHLORIDE FOR THE TREATMENT OF PARKINSON'S DISEASE
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Abstract
Ropinirole Hydrochloride is an Anti-Dyskinesia Agents used in the management of Parkinson's Disease. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film were prepared by using polymers such as Hydroxy propyl methyl cellulose (HPMC) E3, E5, E15 by a solvent casting method. They were evaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and Invitro Dissolution Studies give satisfactory results. The in vitro dissolution time of the optimized batch F5 was found to be 99.04%. The optimized batch in vitro disintegration time was found to 15 sec.
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