Innovat International Journal Of Medical & Pharmaceutical Sciences <p><strong>Innovat International Journal Of Medical &amp; Pharmaceutical Sciences</strong></p> <p>Innovat International journal of Medical &amp; Pharmaceutical Sciences (IIJMPS)(Innov. int. j. med. pharm. sci.) is an Official Publication Innovat Publishers. It is an international Open access online journal published bimonthly.</p> <p>IIJMPS (Innov. int. j. med. pharm. sci.) is available in online and print version.</p> <p>It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report in the field of pharmacy, Novel Drug Delivery, Pharmaceutical Technology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry, Drug Design, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical Pharmacy, Pharmaceutical Biotechnology, Pharmaceutical Microbiologyand medicine its scope includes work that relate with Kidney, Liver, Heart or Bones Nutrition, Ophthalmology, Skin, Lung, Blood, and Brainthat contribute significantly to further the scientific knowledge related to the fields. Articles with timely interest and newer research concepts will be given more preference. All papers are subjected to peer-review.</p> <p><strong>Focus and Scope</strong></p> <p>The journal will cover technical and clinical studies related to medicine and pharmaceutical sciences and in all allied field of them. The primary aim of journal is to promote improvement in Medical and pharmaceutical research. IIJMPS invites articles as original research work, case report and review articles in all areas of medical and pharmaceutical research. This Journal publishes and contributes significantly the scientific knowledge related but not limited to the field of Pharmacy and medical sciences.</p> <p><strong>Abstracting and Indexing-</strong></p> <p>UGC Approved Journal, Google Scholar, J-Gate, CNKI, index Copernicus, DRJI, PKP (Public Knowledge Project), Europub, Scientific Indexing Services (SIS), International Scientific Indexing (ISI), Cosmos, EBSCO.</p> en-US (Dr. Mahesh Bhanudas Narkhede) (Site administrator) Thu, 01 Sep 2022 00:00:00 +0100 OJS 60 CHEMICAL INVESTIGATION, ISOLATION AND BIOACTIVITY TESTING OF PHYTOMOLECULES FROM CYPERUS SCARIOSUS <p><strong><em>Objective: </em></strong><em>The present study was carried out to extract, isolate and evaluate the antimicrobial activity of the root and aerial part of Cyperus scariosus </em>(Nagarmotha).</p> <p><strong>Material and Methods: </strong>In this research, cyperus oil was extracted from the root by various distillation techniques such as Water/hydro distillation (Clevenger apparatus), and Steam distillation (Boiler operated). The root and aerial part of Nagarmotha was extracted in different solvents such as hexane, aqueous, and ethanol and evaluated for antimicrobial activity at different concentrations against 6 gram-positive (<em>Staphylococcus aureus</em>, <em>Streptococcus epidermidis</em>, Bacillus subtilis<em>, Yersinia enterocolitica, Salmonella typhimurium, Enterobacter aerogenes </em>), 1 gram-negative (<em>E.Coli </em>) bacterial strains and 3 fungal strains (<em>Candida albicans, Aspergillus niger, Aspergillus flavus </em>). Amikacin and fluconazole (100 μg/ml) were taken as standard drugs.</p> <p><strong>Result and Discussion: </strong>The % yield of oil was 0.84 % (v/w) by both methods. The Isolated compound was characterized by various spectroscopic techniques such as GC, GC-MS, and 1H NMR and established as (-)-ISOLONGIFOLEN-9-ONE. Root and aerial extract in different solvents showed mild antimicrobial activity at 100 μg/ml. Pure oil (NM Oil) showed mild to moderate antibacterial activity at 100 μg/ml against gram-positive bacteria but it was not shown any activity against gram-negative bacteria. Pure oil was also shown very good activity against fungal strains such as <em>Candida albicans </em>and <em>Aspergillus flavus </em>when compared with the standard drug Fluconazole.</p> <p><strong>Conclusion: </strong>The present study showed that the pure oil obtained from the <em>Cyperus scariosus </em>has the potential to diminish microbial growth and can be effective in the treatment of microbial diseases.</p> PRIYANKA DEWANGAN, SWATI THEPE, LOKKANYA DEWANGAN, NITYAPAL SINGH, ANCHAL VERMA Copyright (c) 2022 Innovat International Journal Of Medical & Pharmaceutical Sciences Thu, 01 Sep 2022 00:00:00 +0100 GLIOBLASTOMA. ASPECTS OF PATHOGENESIS AND THERAPEUTIC APPROACHES <p>Glioblastoma is considered one of the most aggressive malignant brain tumors, which has an extremely unfavorable prognosis and low patient survival. The low sensitivity to standard multimodal therapy is explained by the heterogeneity of the tumor cell pool and the presence of glioblastoma stem-like cells in the tumor. In recent years, much attention has been paid to the identification and study of molecular genetic disorders of glioblastoma. The most significant of them are the IDH1 gene mutation and the MGMT methylation status. Currently, the gold standard of treatment is the use of neuronavigation and intraoperative tumor fluorescence in surgery, these methods allow the most accurate and complete removal of the tumor. In this article, we will consider the pathogenesis, experimental technologies and modern methods of treating this disease.</p> BON L.I., LYCHKOVSKAYA M.A. Copyright (c) 2022 Innovat International Journal Of Medical & Pharmaceutical Sciences Thu, 01 Sep 2022 00:00:00 +0100 SPATIAL MEMORY ASSESSMENT IN RODENTS <p>Stress may be acute, chronic and episodic. Acute and chronic stress may be differentiated on the basis of their onset of action and duration. Different animal models have been used to study and to evaluate the stress disorders including acute stress disorder and post-traumatic stress disorder. In most biomedical research rodents (rats and mice) are used. There are different apparatus ,which are used for the behaviour assessment, like plus-maze apparatus, zero-maze apparatus, T-maze apparatus etc..</p> ANIL KUMAR, SHIVAM SHARMA, VANDANA SHYAM, SHWETA AGGARWAL, PRIYANKA SEN, POONAM SHARMA Copyright (c) 2022 Innovat International Journal Of Medical & Pharmaceutical Sciences Thu, 01 Sep 2022 00:00:00 +0100 SYNERGISTIC IMPACT OF HERBAL MEDICINE IN PEPTIC ULCER <p>Up to 10% of people worldwide are affected by a chronic condition known as peptic ulcer. Peptic ulcer development is influenced by the pH of gastric juice and a decline in mucosal defences. Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory medicines (NSAIDs) are mucosal resistance to the damage being affected by two main elements. Conventional peptic ulcer therapy, Histamine-2 (H2) receptor antagonists, and proton pump inhibitors (PPIs) have shown negative consequences, relapses, and different medication combinations. Contrarily, therapeutic herbs and many illnesses may be prevented and treated with the help of their.</p> SACHIN BHARDWAJ, DIKSHA KAUSHAL, SHWETA AGARWAL, PRIYA THAKUR, CHITRA KAUNDAL, POONAM SHARMA, DAIWAKSHI SHANDIL, ANIL KUMAR Copyright (c) 2022 Innovat International Journal Of Medical & Pharmaceutical Sciences Thu, 01 Sep 2022 00:00:00 +0100