EXCIPIENTS AND ITS VARIATION IN PHARMACEUTICAL AEROSOL FORMULATION: A REVIEW
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Abstract
An aerosol can have variations in formulation as per the area of application and intention of use. In short aerosol formulations are the best NDDS for dispensing Active Pharmaceutical Ingredients (API’s) to the systemic circulation as well as faster local action as compared to OSD. As this dosage form is applied topically, it does not affect the major organs of the body. It has been concluded that it does not show or shows minimum hypersensitivity to locally applied area. It shows best bioavailability as compared to the OSD & desired pharmacological effect. Now a days, new excipients are being used to used get the better formulation efficacy and for batter patient’s compliance. According to the formulation to be processed, we should use specific excipients as conformed by the assay procedure in respective furmularary or pharmacopoeia. From various excipients like colorants, disintigrants, antiadherants, lubricants, sweeteners, binders, flavourin agents, glidants, sorbents, preservatives and vehicles,  various dosage forms were formulated as per target and bioavailability. The present review is based on the excipients used in topical pharmaceutical aerosols and its variations.
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