A.Krishna sailaja, R Supraja


Topical application has many advantages over the conventional dosage forms. In general, they are deemed more effective less toxic than conventional formulations due to the bilayer composition and structure. In the formulation of topical dosage forms,attempts are being made to utilize drug carriers that ensure adequate localization or penetration of the drug within or through the skin in order to enhance the local and minimize the systemic effects, or to ensure adequate percutaneous absorption. Topical preparation avoids the GI-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug. Topical preparations give its action directly at the site of action. In this review a detailed discussion was made on the properties, classification, characterization, preparation and applications of gel.

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