Main Article Content

Maunab Patra
Saswat Ranjan Satapaty
Meenakshi Patnaik


Oral dosage forms are the most popular way of medication but it has some disadvantages like slower absorption rate. This can be avoided by intake of liquid dosage forms. However, it has been found that most of the APIs are unstable in liquid formulation. So, effervescent form of drug delivery has evolved as an alternate way of medication in which drug are found to be stable  as well as easy to administer. In this present review, we are going to discuss about various manufacturing processes and their variations.

Key word: effervescent formulations, manufacturing process, variations, Topo technology.


Download data is not yet available.

Article Details

How to Cite
Patra, M., Satapaty, S. R., & Patnaik, M. (2016). PROCESS & VARIATION IN EFFERVESCENTFORMULATION: A review. Innovat International Journal Of Medical & Pharmaceutical Sciences, 1(1), 1–3.


Patel, H. K.; Chauhan, P. Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen, Int. J. Pharm. Res. Sch.2012, 2(1), 509-520.

Palanisamy, P.; Rabi, A. Formulation and Evaluation of Effervescent Tablets of Aceclofenac. Int. Res. J. Pharm.2011, 2(12), 185-189.

Rajalaxmi, G.; Vamsi, C.H.; Balacharan, R.; Damodaran, N. Formulation and Evaluation of Diclofenac Potassium Effervescent Tablet. Int. J. Pharm. Biomed. Res., 2011, 2(4) 237-243.

Tekade, B.W.; Jadhao, U.T.; Thakre, V.M.; Bhortake, L.R. Formulation And Evaluation Of Diclofenac Sodium Effervescent Tablet, Innovation Pharm. Pharmacotherapy, 2014, 2(2), 350-358

Aslani, A.; Hajar, J.; Formulation, characterization and physiochemical evaluationof Ranitidine effervescent tablets, Adv. Pharm. Bull., 2013, 3(2), 315-322.

Mikvy, W.P.; Tucci, R.J. Zinc and strontium ion containing effervescent mouthwash, tablet, US Patent 3,888,976 , 1975.

Banerjee, N.; Singh, S. Formulation, Evaluation and Optimization of effervescent granules to be reconstituted into suspension of Levetiracetam for sustain release, Int. J. Pharm. Sci. Rev. Res. 20(2), may- Jun 2013, 181-186.

Aberg, T. Tooth cleansing tablet, US patent, 4,753,792, Jun 28, 1988.

Bhattacharyya, S.; Sweta G. Formulation and Evaluation of Effervescent Granules of Fexofenadine Hydrochloride, The Pharm. Innovation, 2014, 3(3),1-8.

Wehling, F.; Schuehle, S. Effervescent dosage form with Microparticles, US patent 5,178,878, jan12, 1993.

Srinath, K.R. Formulation and Evaluation of Effervescent Tablets of Paracetamol, INT. J. Pharm. Res. Dev. 2011. 3(3), 76-104.

Bertuzzi, G. Handbook of pharmaceutical granulation technology, 2005, 365-383.

Liberman, H.A.; Lachman, L.; Schwartz, J.B. Pharmaceutical Dosage Forms: Tablets, V(1)2, 1989, 285-328

Gergly, G. Method for the manufacture of effervescent tablets, Us patent no 3,773,922, Nov 20, 1973.

Staci, L.S.; Randall, R.J.; Joseph, D.A.; Robert, W.F.; Sean, S.D. Process for beverage tablets and products therefrom, US patent no 5,254,355,

Botelho, J.W.; Jacobs, G.F. ; Sheng, H.H.; Winningham, M.J. Secondary coating composition for optical fibers, US patent6775451

Govindarajan, T.; Shandas, R. A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices, Polymers2014, 6(9), 2309-2331

Glien, M.; Brant, C.; Potschka, H.; Loscher, W. Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Pub Med, 2002,43(4), 350-7

Haack, D.; Gergely, I.; Metz, C. The TOPO Granulation Technology Used in the Manufacture of Effervescent TabletsTechnoPharm2012 2, Nr. 3, 186–191

Carlin E.J.; Garruto, F.M.; Effervescent systems with simplified packaging requirements US patent no 3,627,27.

Lee, R.E.; Effervescent tablets, CSC publishing, Tablets & capsules