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Pellets were prepared by extrusion spheronization technique. All the batches of pellets were spherical with good flowability and compressibility. Drug release from the pellets was affected by both % of lactose and % of drug load. % lactose showed positive effect on drug release from the pellets whereas % drug load showed negative effect on drug release from the pellets. Batch B12 was selected as best batch because it had lowest SSR (32.95) and the drug release at  2, 6 and 12 h were within the limits of desired drug release limits. The SEM study of optimized batch pellets showed that the pellets were spherical with compact surface.


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PRAVIN, G., & K NIKAM, V. (2021). FORMULATION DEVELOPMENT AND EVALUATION OF EMTRICITABINE PELLETS BY EXTRUSION SPHERONIZATION TECHNIQUE. Innovat International Journal Of Medical & Pharmaceutical Sciences, 6(1), 1–4. Retrieved from
Original Article(s)


Anand et al. "Effect of different process factors on physical properties of acetaminophen pellts with high drug loading prepared using extrusion spheronization-without a binder." Web.

Basavaiah et al. " Development and validation of stability indicating spectrophotometric methods for determination of oxcarbazepine in pharmaceuticals." Journal of science and industrial research 70 (2011): 346-51. Print.

Cruz-Antonio, HaL. "Differences in the Dissolution Profile, Suggesting a Lower Oral Bioavailability, of a Novel Formulation of Oxcarbazepine (Actinium®) Compared with the Innovator Product (Trileptal®)." Proceeding of Western Pharmacology Society 49 (2006): 83-5. Print.

Daslaniya, Dhiren, Shah, Amarish. " Design development and characterization of extended release multiunit particulate system of anti-inflammatory drug." International Journal of Pharmaceutical Science and Drug Research 1 (2009): 100-102. Print.

Dey and Rao. "Multiparticulate drug delivery systems for controlled release." Tropical Journal of Pharmaceutical Research 7 (2008): 1067-1075. Print.

FDA alert for healthcare. "Hydromorphone hydrochloride extended release capsules (marketed as PalladoneTM)." July 2005.

FDA/CDER. "Guidance for Industry: Food-Effect Bioavailability and Fed Bioequivalence Studies." 2002.

Goskonda et al. "Development of matrix controlled release beads by extrusion- spheronization technology using a statistical screening design." Drug Development and Industrial Pharmacy 20 (1994): 279–292. Print.

Guet al. "Predicting effect of food on extent of drug absorption based on physicochemical properties." Pharmaceutical Research 24 (2007): 1118–1130. Print.

Hausner. "The Role of Interparticle Friction in Powder Technology, in Goeldberg as (Edi.), 1st International Conference on the Compaction and Consolidation of Particulate Matter."Brighton, 1972.7-12. Print.11. Ibrahim, Mohamed. "Formulation and evaluation of mefenamic acid sustained release matrix pellets." ActaPharaceuticam 63 (2013): 85-98. Print.

Kandukuri, Mohan, et al. "Pelletization techniques for oral drug delivery." International Journal of Pharmaceutical Sciences and Drug Research 1 (2009): 63-70. Print.

Kojima and Nakagami. " Development of controlled release matrix pellets by annealing with micronized water-insoluble or enteric polymers." Journal of Controlled Release 82 (2002): 335–343. Print.

Krogars et al. "Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic delivery." International journal of pharmaceutics 199 (2000): 187-194. Print.

Lavanya et al. "Pelletization technology: a quick review." International Journal of Pharmaceutical Sciences and Research 2 (2011): 1337-1355. Print.

Lentz. "Current methods for predicting human food effect." AAPS Journal 10 (2008): 282-88. Print.

Lopes et al. "Analysis of possible food/nutrient and drug interactions in hospitalized patients." Einstein 3.1 (2010): 298–302. Print.

Maka and Murphy. "Drug-nutrient interactions: a review." AACN Clinical Issue 11 (2000): 580–589. Print.

Marasanapalle et al. "Investigation of some factors contributing to negative food effects."Biopharmaceutics and Drug Disposition 30 (2009): 71-80. Print.

Marciani et al. "Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI." American Journal of Physiology - Gastrointestinal and Liver Physiology 280 (2001): G1227–G1233. Print.

Mehta, Ketan et al. "Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug." Journal of Controlled Release 63 (2000): 201-11. Print.

Moneghini et al. "Formulation Design Studies of Atenolol Tablets." Pharmaceutical Development and Technology 5 (2000): 297-301. Print.

Pornsak, Sriamornsak and Benchawan, Chamsai. "Novel disintegrating microcrystalline cellulose pellets with improved drug dissolution performance." Powder Technology 233 (2013): 278-85. Print.

Powder flow, 1174. United state pharmacopoeia.Asian edition ed. Rockville, 2006.

Ropero-Miller Jeri. (Trileptyl®).Oxcarbazepine. 11 February 2013 <>.

Singh. "A quantitative approach to probe the dependence and correlation of food-effect with aqueous solubility, dose/solubility ratio, and partition coefficient (Log P) for orally active drugs administered as immediate-release formulations." Drug Development and Research 65 (2005): 55-75. Print