SAXAGLIPTIN: A SYSTEMATIC REVIEW ON ITS PHARMACOLOGICAL POTENTIAL AND ANALYTICAL ASPECTS
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Abstract
This review highlights the potential indications of Saxagliptin and its combinations including several analytical aspects. The selective, reversible dipeptidyl peptidase-4 inhibitor Saxagliptin and its active metabolite M2 are used to improve the glycaemic control in type 2 diabetic patients. Saxagliptin prevents the inactivation of the incretin hormones namely glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. This increases glucagon-like peptide-1 levels, stimulates insulin secretion and reduces the postprandial glucagon and glucose levels in the body. Saxagliptin therapy in patient with type 2 diabetes are prescribed as monotherapy or as add-on therapy to Metformin, Sulphonyl urea and Thiazolidine-diones, without significant change in body weight while exhibiting a low risk of hypoglycaemia. There is a significant enhancement in the HbA1C levels relative to continued use of existing monotherapy. Some potential indications of Saxagliptin include metabolic disorders, inflammatory disorders, hepatic disorders, neurological disorders and as well as cardiac disease..
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