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Prednisolone sodium phosphate is the glucocorticoid used mainly for inflammation related disorder, asthma, rheumatoid arthritis, etc. Generally liquid dosage forms are frequently preferred over the convectional tablets due to objectionable bitter taste because taste can be diluted with the use of sweeteners or other taste masking techniques. Prednisolone sodium phosphate less stable in the liquid dosage form, for this reason effervescent formulation can be used as the alternative to the liquid dosage form. Effervescent dosage form are quite popular in which tablets is dissolve in glass of water and taken. In this investigation detail study of prednisolone sodium phosphate as effervescent formulation has been carried out.
Orapred ODTâ„¢ (prednisolone sodium phosphate orally disintegrating tablets): Clinical pharmacology. Available from: URL: https://www.rxlist.com/orapred-odt-drug.htm#clinpharm
Soluble Prednisolone 5mg tablets (leaflet). Available from: https://www.medicines.org.uk/emc/product/6706/smpc
EP monograph of prednisolone sodium phosphate: Available from: URL: http://www.uspbpep.com/ep60/prednisolone%20sodium%20phosphate%200735e.pdf
BP 2018. Monograph: medicinal and pharmaceutical substance. Prednisolone sodium phosphate.
Habib W. Kothari B. Prednisolone salt formulation. United states patent; WO2007143131. 2007 Dec 13.
Srinath KR. Chowdary CP. Formulation and evaluation of effervescent tablets of paracetamol. IJPRD; Vol 3(3): 12; 2011 May (76-104); 76
Ipci K. Oktemer T. Birdane L. Altintopark N. Muluk NB. Passali D. Lopatin A. Bellussi L. Mladina R. Pawankar R. Cingi C. Effervescent tablets; a safe and practical delivery system for drug administration. ENT Update. ; 6(1): 46-50: 49. doi:10.2399/jmu.2016001009
Thomas F. â€˜Oâ€™ Brien. Salts, chlor-alkali and Related heavy chemicals. In: Kent JA, Editor. Handbook of industrial chemistry and biotechnology. Vol 01: 12th edition. New York: Springer: p 1017
Sheng Y. Yang X. Pal D. Mitra AK. Prodrug approach to improve absorption of prednisolone. Int J Pharm. 2015 June 20; 487(0): 242â€“249. doi:10.1016/j.ijpharm.2015.04.029.
The European Agency for the evaluation of medicinal products and veterinary medicinal products. Prednisolone. 1999 July. Available from: URL: https://www.ema.europa.eu/documents/mrl-report/prednisolone-free-alcohol-summary-report-committee-veterinary-medicinal-products_en.pdf